Thyroid Stimulating Hormone Receptor (TSHR) Intron 1 Variants Are Major Risk Factors for Graves' Disease in Three European Caucasian Cohorts

BACKGROUND: The thyroid stimulating hormone receptor (TSHR) gene is an established susceptibility locus for Graves' disease (GD), with recent studies refining association to two single nucleotide polymorphisms (SNPs), rs179247 and rs12101255, within TSHR intron 1. METHODOLOGY AND PRINCIPAL FIND...

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Auteurs principaux: Płoski, Rafał, Brand, Oliver J., Jurecka-Lubieniecka, Beata, Franaszczyk, Maria, Kula, Dorota, Krajewski, Paweł, Karamat, Muhammad A., Simmonds, Matthew J., Franklyn, Jayne A., Gough, Stephen C. L., Jarząb, Barbara, Bednarczuk, Tomasz
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991361/
https://ncbi.nlm.nih.gov/pubmed/21124799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015512
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