Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

INTRODUCTION: The purpose of the present manuscript is to test the hypothesis that arthrotropic localization and synovial cell internalization account for the unique capacity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-dexamethasone conjugate (P-Dex, a macromolecular prodrug of dexamethaso...

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Detalhes bibliográficos
Main Authors: Quan, Ling-dong, Purdue, P Edward, Liu, Xin-ming, Boska, Michael D, Lele, Subodh M, Thiele, Geoffrey M, Mikuls, Ted R, Dou, Huanyu, Goldring, Steven R, Wang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990997/
https://ncbi.nlm.nih.gov/pubmed/20836843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3130
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