The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation

Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcriptionally active molecule. The Notch1 receptor was...

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Bibliografiske detaljer
Main Authors: Moretti, Julien, Chastagner, Patricia, Gastaldello, Stefano, Heuss, Sara F., Dirac, Annette M., Bernards, René, Masucci, Maria G., Israël, Alain, Brou, Christel
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990700/
https://ncbi.nlm.nih.gov/pubmed/21124883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000545
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