PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer

PURPOSE: Tumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1α. The effects of PHD3 in tumour growth are largely unknown. EXPERIMENTAL DESIGN: PHD3 expression was analysed in hu...

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Autors principals: Su, Y, Loos, M, Giese, N, Hines, O J, Diebold, I, Görlach, A, Metzen, E, Pastorekova, S, Friess, H, Büchler, P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990580/
https://ncbi.nlm.nih.gov/pubmed/20978507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605936
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