Immunization with Pneumolysin Protects Against Both Retinal and Global Damage Caused by Streptococcus pneumoniae Endophthalmitis

PURPOSE: To determine whether immunization with pneumolysin (PLY) protects against pneumococcal endophthalmitis. METHODS: New Zealand white rabbits were immunized with a mutant form of PLY that retains only 1% of its cytolytic activity until serum IgG titers were ≥51,200. For a negative control, rab...

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Detalhes bibliográficos
Main Authors: Sanders, Melissa E., Norcross, Erin W., Moore, Quincy C., Fratkin, Jonathan, Thompson, Hilary, Marquart, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990286/
https://ncbi.nlm.nih.gov/pubmed/21034245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2010.0077
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