A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility

More than 25 loci have been linked to type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse, but identification of the underlying genes remains challenging. We describe here the positional cloning of a T1D susceptibility locus, Idd11, located on mouse chromosome 4. Sequence analysis of a series...

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Autori principali: Tan, Iris K.L., Mackin, Leanne, Wang, Nancy, Papenfuss, Anthony T., Elso, Colleen M., Ashton, Michelle P., Quirk, Fiona, Phipson, Belinda, Bahlo, Melanie, Speed, Terence P., Smyth, Gordon K., Morahan, Grant, Brodnicki, Thomas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989989/
https://ncbi.nlm.nih.gov/pubmed/21051460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.101881.109
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