Activation of FOXO transcription factors by oncogenic BRAF promotes p21(cip1)-dependent senescence

Oncogene-induced senescence (OIS) is a potent tumor suppressive mechanism that is thought to come at the cost of aging. The Forkhead Box O (FOXO) transcription factors are regulators of lifespan and tumor suppression. However, whether and how FOXOs function in OIS has been unclear. Here, we demonstr...

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Main Authors: de Keizer, Peter L.J., Packer, Leisl M., Szypowska, Anna A., Riedl-Polderman, Paulien E., van den Broek, Niels J.F., de Bruin, Alain, Dansen, Tobias B., Marais, Richard, Brenkman, Arjan B., Burgering, Boudewijn M.T.
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989643/
https://ncbi.nlm.nih.gov/pubmed/20959475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1563
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