Mdm2 Induces Mono-Ubiquitination of FOXO4

BACKGROUND: The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and apoptosis. Furthermore, in model organisms FOXOs act as tumor suppressors and affect aging. Previously, we noted that FOXOs and p53 a...

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Hauptverfasser: Brenkman, Arjan B., de Keizer, Peter L. J., van den Broek, Niels J. F., Jochemsen, A. G., Burgering, Boudewijn M. Th.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475507/
https://ncbi.nlm.nih.gov/pubmed/18665269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002819
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