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Extensive families of constant region genes in a phylogenetically primitive vertebrate indicate an additional level of immunoglobulin complexity.

A homologous probe for the constant region of the Heterodontus francisci (horned shark) immunoglobulin heavy chain was used to screen a genomic DNA library constructed in bacteriophage lambda, and a large number of independent clones were recovered. Their hybridization patterns with segment-specific...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kokubu, F, Hinds, K, Litman, R, Shamblott, M J, Litman, G W
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1987
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298964/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3475706/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.16.5868
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