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Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity

PURPOSE: Development of novel agents and drug combinations are urgently needed for treatment of pancreatic cancer. Oxaliplatin belongs to an important class of DNA-damaging organoplatinum agents, useful in pancreatic cancer therapy. However, increased ability of cancer cells to recognize and repair...

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Sonraí Bibleagrafaíochta
Main Authors: Melisi, Davide, Ossovskaya, Valeria, Zhu, Cihui, Rosa, Roberta, Ling, Jianhua, Dougherty, Patrick M., Sherman, Barry M., Abbruzzese, James L., Chiao, Paul J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989607/
https://ncbi.nlm.nih.gov/pubmed/19808866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0910
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