The TNF-α antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus

Chronic inflammation has been implicated in the pathology of hypertension; however, the role for specific cytokines remains unclear. We tested whether TNF-α blockade with etanercept (Etan) reduces mean arterial pressure (MAP) in a female mouse model of systemic lupus erythematosus (SLE). SLE is a ch...

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Autors principals: Venegas-Pont, Marcia, Manigrasso, Michaele B., Grifoni, Samira C., LaMarca, Babbette B., Maric, Christine, Racusen, Lorraine C., Glover, Porter H., Jones, Allison V., Drummond, Heather A., Ryan, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989495/
https://ncbi.nlm.nih.gov/pubmed/20696988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.110.157685
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