DNA Damage Induced by Alkylating Agents and Repair Pathways

The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms. N-methylations are removed by base excision repair, AlkB homologues, or nucleot...

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Bibliographic Details
Main Authors: Kondo, Natsuko, Takahashi, Akihisa, Ono, Koji, Ohnishi, Takeo
Format: Artigo
Language:Inglês
Published: SAGE-Hindawi Access to Research 2010
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989456/
https://ncbi.nlm.nih.gov/pubmed/21113301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/543531
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