Increasing CD44(+)/CD24(- )tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis

BACKGROUND: Cancer cells are believed to arise primarily from stem cells. CD44(+)/CD24(- )have been identified as markers for human breast cancer stem cells. Although, HER2 is a well known breast cancer oncogene, the mechanisms of action of this gene are not completely understood. Previously, we hav...

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Autors principals: Wang, Kai-Hung, Kao, An-Pei, Chang, Chia-Cheng, Lee, Jau-Nan, Hou, Ming-Feng, Long, Cheng-Yu, Chen, Hung-Sheng, Tsai, Eing-Mei
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989327/
https://ncbi.nlm.nih.gov/pubmed/21044318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-288
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