A Functional Polymorphism in PIN1 that Prevents its Suppression by AP4 Is Associated with Delayed Onset of Alzheimer’s disease

Alzheimer’s disease (AD), the most common form of dementia, is characterized by the presence of neurofibrillary tangles composed of tau and senile plaques of amyloid-beta peptides (Aβ) derived from amyloid precursor protein (APP). Pin1 is a unique prolyl isomerase that has been shown to protect agai...

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Detalhes bibliográficos
Main Authors: Ma, Suk Ling, Tang, Nelson Leung Sang, Tam, Cindy Woon Chi, Lui, Victor Wing Cheong, Lam, Linda Chiu Wa, Chiu, Helen Fung Kum, Driver, Jane Ann, Pastorino, Lucia, Lu, Kun Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988914/
https://ncbi.nlm.nih.gov/pubmed/20580132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.05.018
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