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On the Mechanism of Chloroquine Resistance in Plasmodium falciparum

Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a ca...

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Detalhes bibliográficos
Main Authors: Chinappi, Mauro, Via, Allegra, Marcatili, Paolo, Tramontano, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988812/
https://ncbi.nlm.nih.gov/pubmed/21124966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014064
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