Targeted Disruption of Ing2 Results in Defective Spermatogenesis and Development of Soft-Tissue Sarcomas

ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors. As part of mSin3A-HDAC corepressor complexes, ING2 binds to tri-methylated lysine 4 of histone H3 (H3K4me3) to regulate chromatin modification and gene expressi...

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Hauptverfasser: Saito, Motonobu, Kumamoto, Kensuke, Robles, Ana I., Horikawa, Izumi, Furusato, Bungo, Okamura, Shu, Goto, Akiteru, Yamashita, Taro, Nagashima, Makoto, Lee, Tin-Lap, Baxendale, Vanessa J., Rennert, Owen M., Takenoshita, Seiichi, Yokota, Jun, Sesterhenn, Isabell A., Trivers, Glenwood E., Hussain, S. Perwez, Harris, Curtis C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988811/
https://ncbi.nlm.nih.gov/pubmed/21124965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015541
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