Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions.

The liver is an important target for potential gene therapy because of the critical role it plays in intermediary metabolism and synthesis of serum proteins. We report the use of retroviral vectors for transfer of recombinant genes into primary mouse hepatocytes. Hepatocytes were grown in a defined...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ledley, F D, Darlington, G J, Hahn, T, Woo, S L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298850/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3474659/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.15.5335
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