The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor 4 at the Sorting Endosome

Reversible ubiquitination orchestrated by the opposition of ubiquitin ligases and deubiquitinating enzymes mediates endocytic trafficking of cell surface receptors for lysosomal degradation. Ubiquitin-specific protease 8 (USP8) has previously been implicated in endocytosis of several receptors by vi...

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Bibliographic Details
Main Authors: Berlin, Ilana, Higginbotham, Katherine M., Dise, Rebecca S., Sierra, Maria I., Nash, Piers D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988392/
https://ncbi.nlm.nih.gov/pubmed/20876529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129411
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