Phosphorylation of Enoyl-Acyl Carrier Protein Reductase InhA Impacts Mycobacterial Growth and Survival

InhA, the primary target for the first line anti-tuberculosis drug isoniazid, is a key enzyme of the fatty-acid synthase II system involved in mycolic acid biosynthesis in Mycobacterium tuberculosis. In this study, we show that InhA is a substrate for mycobacterial serine/threonine protein kinases....

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Main Authors: Khan, Shazia, Nagarajan, Sathya Narayanan, Parikh, Amit, Samantaray, Sharmishtha, Singh, Albel, Kumar, Devanand, Roy, Rajendra P., Bhatt, Apoorva, Nandicoori, Vinay Kumar
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988389/
https://ncbi.nlm.nih.gov/pubmed/20864541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143131
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