The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression

The p53 tumor suppressor protein is regulated by multiple post-translational modifications, including lysine methylation. We previously found that monomethylation of p53 at lysine 382 (p53K382me1) by the protein lysine methyltransferase (PKMT) SET8/PR-Set7 represses p53 transactivation of target gen...

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Détails bibliographiques
Auteurs principaux: West, Lisandra E., Roy, Siddhartha, Lachmi-Weiner, Karin, Hayashi, Ryo, Shi, Xiaobing, Appella, Ettore, Kutateladze, Tatiana G., Gozani, Or
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988377/
https://ncbi.nlm.nih.gov/pubmed/20870725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.139527
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