A Phase I and Biology Study of Gefitinib and Radiation in Children with Newly Diagnosed Brain Stem Gliomas or Supratentorial Malignant Gliomas

PURPOSE: To estimate the maximum tolerated dose (MTD); study the pharmacology of escalating doses of gefitinib combined with radiation therapy in patients ≤21 years with newly diagnosed intrinsic brainstem gliomas (BSG) and incompletely resected supratentorial malignant gliomas (STMG); and to invest...

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Detalhes bibliográficos
Main Authors: Geyer, J. Russell, Stewart, Clinton F., Kocak, Mehmet, Broniscer, Alberto, Phillips, Peter, Douglas, James G., Blaney, Susan M., Packer, Roger J., Gururangan, Sri, Banerjee, Anu, Kieran, Mark W., Kun, Larry E., Gilbertson, Richard J., Boyett, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988095/
https://ncbi.nlm.nih.gov/pubmed/20708924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.07.005
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