Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

BACKGROUND: Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and resistance to glucocorticoids (GCs). We have recently observed that GC resistance in T-ALL cell lines is associated with a prolife...

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Main Authors: Beesley, Alex H, Rampellini, Janelle L, Palmer, Misty-Lee, Heng, Jasmin YS, Samuels, Amy L, Firth, Martin J, Ford, Jette, Kees, Ursula R
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987983/
https://ncbi.nlm.nih.gov/pubmed/20979663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-284
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