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How Cations Can Assist DNase I in DNA Binding and Hydrolysis
DNase I requires Ca(2+) and Mg(2+) for hydrolyzing double-stranded DNA. However, the number and the location of DNase I ion-binding sites remain unclear, as well as the role of these counter-ions. Using molecular dynamics simulations, we show that bovine pancreatic (bp) DNase I contains four ion-bin...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2987838/ https://ncbi.nlm.nih.gov/pubmed/21124947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001000 |
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