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Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

T cell antigen receptor (TCR) diversity is a critical feature of adaptive immunity. However, restriction of TCR diversity is a potential risk during immune reconstitution by homeostatic proliferation. What peripheral mechanisms are in place to maintain TCR diversity during recovery from lymphopenia?...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Moses, Christina T., Thorstenson, Kristen M., Jameson, Stephen C., Khoruts, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298748/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12525694/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0334572100
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