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A powerful score test to detect positive selection in genome-wide scans

One of the surest signatures of recent positive selection is a local elevation of advantageous allele frequency and linkage disequilibrium (LD). We proposed to detect such hitchhiking effects by using extended stretches of homozygosity as a surrogate indicator of recent positive selection. An extend...

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Autori principali: Zhong, Ming, Lange, Kenneth, Papp, Jeanette C, Fan, Ruzong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987455/
https://ncbi.nlm.nih.gov/pubmed/20461112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2010.60
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