A sequence variant on 17q21 is associated with age at onset and severity of asthma

A sequence variant (rs7216389-T) near the ORMDL3 gene on chromosome 17q21 was recently found to be associated with childhood asthma. We sought to evaluate the effect of rs7216389-T on asthma subphenotypes and its correlation with expression levels of neighboring genes. The association of rs7216389-T...

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Huvudupphovsmän: Halapi, Eva, Gudbjartsson, Daniel F, Jonsdottir, Gudrun M, Bjornsdottir, Unnur S, Thorleifsson, Gudmar, Helgadottir, Hafdis, Williams, Carolyn, Koppelman, Gerard H, Heinzmann, Andrea, Boezen, H Marike, Jonasdottir, Aslaug, Blondal, Thorarinn, Gudjonsson, Sigurjon A, Jonasdottir, Adalbjorg, Thorlacius, Theodora, Henry, Amanda P, Altmueller, Janine, Krueger, Marcus, Shin, Hyoung Doo, Uh, Soo-Taek, Cheong, Hyun Sub, Jonsdottir, Brynja, Ludviksson, Bjorn R, Ludviksdottir, Dora, Gislason, David, Park, Choon-Sik, Deichmann, Klaus, Thompson, Philip J, Wjst, Matthias, Hall, Ian P, Postma, Dirkje S, Gislason, Thorarinn, Kong, Augustine, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Stefansson, Kari
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987388/
https://ncbi.nlm.nih.gov/pubmed/20372189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2010.38
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