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Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated. Large-scale screening of the mtDNA main control region in leukocytes from subjects of an Italian population revealed a homoplasmic C150T tr...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zhang, Jin, Asin-Cayuela, Jordi, Fish, Jennifer, Michikawa, Yuichi, Bonafé, Massimiliano, Olivieri, Fabiola, Passarino, Giuseppe, De Benedictis, Giovanna, Franceschi, Claudio, Attardi, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298736/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12538859/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.242719399
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