Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated. Large-scale screening of the mtDNA main control region in leukocytes from subjects of an Italian population revealed a homoplasmic C150T tr...

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Detalhes bibliográficos
Main Authors: Zhang, Jin, Asin-Cayuela, Jordi, Fish, Jennifer, Michikawa, Yuichi, Bonafé, Massimiliano, Olivieri, Fabiola, Passarino, Giuseppe, De Benedictis, Giovanna, Franceschi, Claudio, Attardi, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC298736/
https://ncbi.nlm.nih.gov/pubmed/12538859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242719399
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