A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis

A rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (MS) in recent studies. However, because of the low frequency of the minor allele (minor allele frequency=0.04), genome-wide significant association has been hard to establish. We genoty...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Mero, Inger-Lise, Lorentzen, Åslaug R, Ban, Maria, Smestad, Cathrine, Celius, Elisabeth G, Aarseth, Jan H, Myhr, Kjell-Morten, Link, Jenny, Hillert, Jan, Olsson, Tomas, Kockum, Ingrid, Masterman, Thomas, Oturai, Annette Bang, Søndergaard, Helle Bach, Sellebjerg, Finn, Saarela, Janna, Kemppinen, Anu, Elovaara, Irina, Spurkland, Anne, Dudbridge, Frank, Lie, Benedicte A, Harbo, Hanne F
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2010
Aiheet:
Short Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987240/
https://ncbi.nlm.nih.gov/pubmed/19888296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2009.195
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