Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk

Pituitary tumor development involves clonal expansion stimulated by hormones and growth factors/cytokines. Using mRNA differential display, we found that the bone morphogenetic protein (BMP) inhibitor noggin is down-regulated in prolactinomas from dopamine D2-receptor-deficient mice. BMP-4 is overex...

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Bibliographische Detailangaben
Hauptverfasser: Páez-Pereda, Marcelo, Giacomini, Damiana, Refojo, Damian, Nagashima, Alberto Carbia, Hopfner, Ursula, Grübler, Yvonne, Chervin, Alberto, Goldberg, Victoria, Goya, Rodolfo, Hentges, Shane T., Low, Malcolm J., Holsboer, Florian, Stalla, Günter K., Arzt, Eduardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC298721/
https://ncbi.nlm.nih.gov/pubmed/12552124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237312100
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