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Evolution of feedback-inhibited β/α barrel isoenzymes by gene duplication and a single mutation
The β/α barrel is the common protein fold of numerous enzymes and was proposed recently to be the result of gene duplication and fusion of an ancient half-barrel. The initial enzyme of shikimate biosynthesis possesses the additional feature of feedback regulation. The crystal structure and kinetic s...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC298692/ https://ncbi.nlm.nih.gov/pubmed/12540830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0337566100 |
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