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Reactivity-based one-pot total synthesis of fucose GM(1) oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer

The total synthesis of the sialic acid-containing antigenic epitope fucose GM(1) (Fuc-GM(1)) by an improved reactivity-based one-pot synthetic strategy is reported. Based on a thioglycoside reactivity database, three saccharide building blocks, 3, 4, and 5, were designed and prepared to incorporate...

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Bibliografiska uppgifter
Huvudupphovsmän: Mong, Tony Kwok-Kong, Lee, Hing-Ken, Durón, Sergio G., Wong, Chi-Huey
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2003
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC298681/
https://ncbi.nlm.nih.gov/pubmed/12552090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0337590100
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