HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

Susceptibility to rheumatoid arthritis (RA) may be due to the presence of shared functional epitopes common to the HLA-DR beta chains of several RA-associated haplotypes. We have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 gene...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wordsworth, B P, Lanchbury, J S, Sakkas, L I, Welsh, K I, Panayi, G S, Bell, J I
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1989
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298641/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2481309/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.10049
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