HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

Susceptibility to rheumatoid arthritis (RA) may be due to the presence of shared functional epitopes common to the HLA-DR beta chains of several RA-associated haplotypes. We have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 gene...

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Detalhes bibliográficos
Main Authors: Wordsworth, B P, Lanchbury, J S, Sakkas, L I, Welsh, K I, Panayi, G S, Bell, J I
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC298641/
https://ncbi.nlm.nih.gov/pubmed/2481309
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