Conformational characterization of a single-site mutant of murine epidermal growth factor (EGF) by 1H NMR provides evidence that leucine-47 is involved in the interactions with the EGF receptor.

Epidermal growth factor (EGF) is a small protein containing 53 amino acids and three disulfide bonds. There is significant current interest in structure-function relationships in EGF and EGF-like proteins, including the homologous type-alpha transforming growth factors. The Leu-47 residue of murine...

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Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Moy, F J, Scheraga, H A, Liu, J F, Wu, R, Montelione, G T
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1989
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2690076/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.9836
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