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The Flory isolated-pair hypothesis is not valid for polypeptide chains: Implications for protein folding

Using an all-atom representation, we exhaustively enumerate all sterically allowed conformations for short polyalanyl chains. Only intrachain interactions are considered, including one adjustable parameter, a favorable backbone energy (e.g., a peptide hydrogen bond). The counting is used to reevalua...

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Detalhes bibliográficos
Main Authors: Pappu, Rohit V., Srinivasan, Rajgopal, Rose, George D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18804/
https://ncbi.nlm.nih.gov/pubmed/11070081
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