N-acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits.

The New Zealand White rabbit provides a widely used animal model for the human acetylation polymorphism, which confers marked interindividual variation in the effect and toxicity of numerous drugs, chemicals, and potential carcinogens. The relationship of a recently isolated cDNA clone, designated r...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Blum, M, Grant, D M, Demierre, A, Meyer, U A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298535/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2594784/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.23.9554
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