The insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells.
Insulin is the only hormone required for continued growth of Chinese hamster ovary CHO-K1 cells in the defined medium M-F12. When CHO-K1 cells are incubated in M-F12 without insulin for 48-72 hr, the cells accumulate in G1. In response to physiological concentrations of insulin an 18-fold increase i...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1989
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298481/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2687878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.23.9294 |
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