Clustered O-Glycans of IgA1: DEFINING MACRO- AND MICROHETEROGENEITY BY USE OF ELECTRON CAPTURE/TRANSFER DISSOCIATION

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Aberrantly glycosylated IgA1, with galactose (Gal)-deficient hinge region (HR) O-glycans, plays a pivotal role in the pathogenesis of the disease. It is not known whether the glycosylation defect occurs randomly or pr...

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Autors principals: Takahashi, Kazuo, Wall, Stephanie B., Suzuki, Hitoshi, Smith, Archer D., Hall, Stacy, Poulsen, Knud, Kilian, Mogens, Mobley, James A., Julian, Bruce A., Mestecky, Jiri, Novak, Jan, Renfrow, Matthew B.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984237/
https://ncbi.nlm.nih.gov/pubmed/20823119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.001834
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