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An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation

In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation of endocardial cells and that its deletion therein results in fully penetrant, d...

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Autori principali: Nadeau, Mathieu, Georges, Romain O., Laforest, Brigitte, Yamak, Abir, Lefebvre, Chantal, Beauregard, Janie, Paradis, Pierre, Bruneau, Benoit G., Andelfinger, Gregor, Nemer, Mona
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984205/
https://ncbi.nlm.nih.gov/pubmed/20974940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914888107
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