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Experimental pancreatitis is mediated by low-affinity cholecystokinin receptors that inhibit digestive enzyme secretion.

Rats infused with a supramaximally stimulating dose of the cholecystokinin (CCK) analog caerulein develop acute edematous pancreatitis. Using CCK-JMV-180, a recently developed CCK analog that acts as an agonist at high-affinity CCK receptors but antagonizes the effect of CCK at low-affinity receptor...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Saluja, A K, Saluja, M, Printz, H, Zavertnik, A, Sengupta, A, Steer, M L
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1989
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298412/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2479032/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.22.8968
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