Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA

An aromatic amine, o-anisidine (2-methoxyaniline) and its oxidative counterpart, 2-nitroanisole (2-methoxynitrobenzene), are the industrial and environmental pollutants causing tumors of the urinary bladder in rats and mice. Both carcinogens are activated to the same proximate carcinogenic metabolit...

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Hlavní autoři: Stiborová, Marie, Naiman, Karel, Martínková, Markéta, Martínek, Václav, Svobodová, Martina, Schmeiser, Heinz H., Frei, Eva
Médium: Artigo
Jazyk:Inglês
Vydáno: Slovak Toxicology Society SETOX 2009
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984092/
https://ncbi.nlm.nih.gov/pubmed/21217841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/v10102-009-0004-4
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