Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss. By means of long-term two-photon in vivo imaging and confocal imaging, we characterized the spatio-temporal pattern of de...

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Bibliografiska uppgifter
Huvudupphovsmän: Bittner, Tobias, Fuhrmann, Martin, Burgold, Steffen, Ochs, Simon M., Hoffmann, Nadine, Mitteregger, Gerda, Kretzschmar, Hans, LaFerla, Frank M., Herms, Jochen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982845/
https://ncbi.nlm.nih.gov/pubmed/21103384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015477
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