Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

The function of lysosomes relies on the ability of the lysosomal membrane to fuse with several target membranes in the cell. It is known that in lysosomal storage disorders (LSDs), lysosomal accumulation of several types of substrates is associated with lysosomal dysfunction and impairment of endocy...

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Detalhes bibliográficos
Main Authors: Fraldi, Alessandro, Annunziata, Fabio, Lombardi, Alessia, Kaiser, Hermann-Josef, Medina, Diego Luis, Spampanato, Carmine, Fedele, Anthony Olind, Polishchuk, Roman, Sorrentino, Nicolina Cristina, Simons, Kai, Ballabio, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982760/
https://ncbi.nlm.nih.gov/pubmed/20871593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.237
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