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Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

Distinct genes encode alpha and beta platelet-derived growth factor (PDGF) receptors that differ in their abilities to be triggered by three dimeric forms of the PDGF molecule. We show that PDGF-receptor mitogenic function can be reconstituted in a naive hematopoietic cell line by introduction of ex...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Matsui, T, Pierce, J H, Fleming, T P, Greenberger, J S, LaRochelle, W J, Ruggiero, M, Aaronson, S A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298271/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2554309/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8314
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