Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease.

Protease nexin-1 (PN-1) is a cell-secreted protein that inhibits certain proteases, particularly thrombin, by forming SDS-stable complexes with the catalytic site serine of the protease. PN-1 was recently shown to be identical to a glial-derived neurite-promoting factor/glial-derived nexin present i...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Wagner, S L, Geddes, J W, Cotman, C W, Lau, A L, Gurwitz, D, Isackson, P J, Cunningham, D D
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298265/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8284
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