Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
To probe the nature of the hydrophobic cores of proteins and to test potential ways of increasing protein thermostability, an attempt was made to improve the packing within T4 bacteriophage lysozyme by engineered amino acid replacements. Two mutations, Leu-133----Phe and Ala-129----Val, which were d...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1989
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298255/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2682639/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8237 |
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