Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
To probe the nature of the hydrophobic cores of proteins and to test potential ways of increasing protein thermostability, an attempt was made to improve the packing within T4 bacteriophage lysozyme by engineered amino acid replacements. Two mutations, Leu-133----Phe and Ala-129----Val, which were d...
Gespeichert in:
| Veröffentlicht in: | Proc Natl Acad Sci U S A |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1989
|
| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298255/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2682639/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8237 |
| Tags: |
Keine Tags, Fügen Sie das erste Tag hinzu!
|