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Evolutionary origin of a secondary structure: π-helices as cryptic but widespread insertional variations of α-helices enhancing protein functionality
Formally annotated π-helices are rare in protein structure but have been correlated with functional sites. Here, we analyze protein structures to show that π-helices are the same as structures known as α-bulges, α-aneurisms, π-bulges, and looping-outs and are evolutionarily derived by the insertion...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981643/ https://ncbi.nlm.nih.gov/pubmed/20888342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.034 |
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