Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells.

Two forms of erythropoietin, EPO-bi and EPO-tetra, with different biological activities were isolated from the culture medium of a recombinant Chinese hamster ovary cell line, B8-300, into which the human erythropoietin gene had been introduced. EPO-bi, an unusual form, showed only one-seventh the i...

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Detalhes bibliográficos
Main Authors: Takeuchi, M, Inoue, N, Strickland, T W, Kubota, M, Wada, M, Shimizu, R, Hoshi, S, Kozutsumi, H, Takasaki, S, Kobata, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC298162/
https://ncbi.nlm.nih.gov/pubmed/2813359
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